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Moreover, gut hormones, such as peptide YY, ghrelin, and oxyntomodulin, are also influenced by gut microbiota to participate in nutrient intake and metabolism [2629]

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There are no concerns regarding topical or oral supplementation in doses up to 500 mg daily

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According to the study, UA had a direct proinflammatory effect on human macrophages manifested by increased macrophage phagocytic activity, the production of TNF-alpha and toll-like receptor 4 (TLR4), and downregulated the urate anion transporter 1 expression. [ Uric acid is believed to contribute to the antioxidant potential in plasma but within the cell it is rather pro-oxidant