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Ultrasound 5 , 24 (2017)

However, conventional meta-analyses are typically limited to pairwise comparisons and are unable to simultaneously evaluate multiple GLP-1RAs, which restricts their clinical applicability

ArmstrongMJHullDGuoKBartonDHazlehurstJMGathercoleLLet al

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In addition to their insulinotropic effects, GIP and GLP-1 play critical roles in various biological processes in different tissues and organs that express GIPR and GLP-1R, including the pancreas, fat, bone and the brain

Rarely, dose adjustment downward becomes necessary if tolerability cannot be managed