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Participants consumed fewer calories per day without being instructed to dietconsistent with appetite and satiety signaling reported in published trials
More importantly, the hazard ratio for major adverse cardiovascular events (including cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina) for the pooled tirzepatide groups versus glargine was 0.74 (95% CI 0.511.08), suggesting no increased cardiovascular risk with tirzepatide compared to insulin glargine
Prescription approval is not guaranteed
Szabo S, et al
The data on GLP-1s shows similar effects: The same cellular receptors that the drugs work on in the brain are found in the lungs, and GLP-1s are also thought to calm airway hyper-responsiveness
It was approved in 2010 to reduce abdominal fat accumulation seen in HIV patients diagnosed with lipodystrophy, a condition of fatty accumulation around the abdomen
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