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In the 68-week trials 7,9 , reductions in weight, waist circumference, blood pressure and HbA 1c appeared to plateau around week 60 with semaglutide

If you have a severe vitamin B12 or dont absorb nutrients because you have a medical condition, injections deliver a B12 boost directly to your bloodstream

Most evidence is still early-stage or preclinical

No washout periods were required

Target pathway semaglutide/tirzepatide: gut-brain axis, insulin secretion, appetite

Similarly, individuals with Crohns disease or ulcerative colitis may experience compromised B12 absorption, and injections can be an effective way to address this