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To determine the optimal concentration of Ex-4, we treated the steatotic cells with increasing concentrations of Ex-4 from 0 to 1 mM and with different incubation periods (3, 6, 12, and 24 h)
doi: 10.2147/OTT 72 Bjerre KnudsenLMadsenLWAndersenSAlmholtKde BoerASDruckerDJet al
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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured
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