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Despite reasonably successful progress in clinical trials of its most advanced oral candidate danuglipron, the company halted development in April, owing to a possible drug-induced liver injury in one participant of an earlier study
They include Dulaglutide (Trulicity) and Liraglutide (Victoza / Saxenda)
Laboratory measurements and disease activity based on the British Isles Lupus Assessment Group (BILAG) and SLE Disease Activity Index (SLEDAI) were determined before the initiation of treatment and after the study time period
Gastrointestinal adverse events Compared with placebo, nausea was more frequent with all tirzepatide doses, especially 15 mg (OR 5.60 [95% CI 3.12, 10.06], I 2 0%) (Table 2)
