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Other studies in Guinea pigs, rabbits, and mice showed a distinct role of the immune system in the formation of PGN-induced ulcers, in particular, the infiltration of PMNs into the site of the lesions and the uptake of PGN by macrophages, resulting in a release of lysosomal enzymes, further damaging the surrounding tissue (Grasso et al

Reactivation of EBV and CMV in severe COVID-19-epiphenomena or trigger of hyperinflammation in need of treatment