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Some studies revealed that because of high concentration in plasma, UA can act as a pro-oxidant within the cell by scavenging and creating ROS or it can act as an antioxidant, which mainly occurs in plasma [122,123,124]
Achieving efficacy with GLP-1 agonists is no longer the primary challenge
They modify hormone signaling, metabolic rate, appetite, or fat mobilization throughout the entire body
Third, at the clinical interface, multicenter PD biobanks and retrospective cohorts should be established to validate the association of GPX4, ACSL4, and related biomarkers with motor progression and cognitive decline
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