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Lancet 402(10401):529544 Papageorgiou M, Biver E (2023) Bone consequences of intentional weight loss in overweight or obese patients

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Since pivotal randomized trials showed no effect modification in the relative reduction in major adverse cardiovascular events by the presence of CKD, it is likely that the absolute benefit of SGLT2i is greater among individuals with HFrEF with CKD, compared with individuals with HFrEF without CKD

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