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Therefore, HB and MCFAs could both act to upregulate PGC-1, triggering antioxidant response and improving cellular energetics through mitochondrial biogenesis (Figure 2)
The literature search was conducted on PubMed, Embase, and Web of Science databases and evaluated GLP-1 RA monotherapies, including dulaglutide, exenatide, liraglutide, lixisenatide, and semaglutide
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It is possible that HbA1c reduction with GLP-1RAs could reflect other biological changes such as reduced insulin resistance, reduced visceral adiposity, and reduced inflammation, which could all be directly involved in GLP-1RA-mediated stroke protection