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Whether toxicity might occur at somewhat lower doses is unknown

Taken together, our data support the view that mitochondrial activation is an early, conserved, and functionally integrated feature of neuronal differentiation, during which neurons establish a metabolically flexible phenotype combining sustained glycolytic activity with enhanced OXPHOS

Cuadrado and colleagues first showed that GSK-3 inhibits NRF2 activity, but the identification of sites in NRF2 that are phosphorylated by GSK-3 was achieved several years later using two-dimensional electrophoresis and mass spectrometry: GSK-3 phosphorylates a group of Ser residues at the level of DSGIS motif in the Neh6 domain of NRF2, and this event represents the signal for the recognition by the adapter protein -TrCP, that targets NRF2 for ubiquitination and proteasomal degradation in a KEAP1-independent manner [150, 151]

Using a properly dosed, well-formulated GHK-Cu product consistently is what allows the cumulative effect to occur.

Third-party HPLC validated to 99%+ purity

It doesnt replace hard work and proper nutrition, but it may help you get better results from your efforts