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The oxidative stress caused by a decrease in GSH levels can then impact microglia function and potentially lead to a more pro-inflammatory M1 phenotype that has reduced -amyloid clearance capabilities (Vilhardt et al., 2017)

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In laboratory and pre-clinical research settings, FOXO4-DRI is used as the primary peptide tool for selective senescent cell elimination a strategy known as senolysis

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albicans ) can be commensal when the host is healthy, but they can invade and cause infection when the intestinal barrier function is impaired and/or the hosts immune function is weakened 109