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Computational and Theoretical Chemistry , 1227, 114227
Upon oxidative stress, sudden MPT causes massive ion influx that dissipates mitochondrial membrane potential and shuts down OXPHOS, ATP production and ROS overgeneration
Ilango S, Paital B, Jayachandran P, Padma PR, Nirmaladevi R (2020) Epigenetic alterations in cancer
Another study published in 2024 by Vleminckx et al
Connection 4 BH4 Depletion and eNOS Uncoupling Beyond Homocysteine Beyond its homocysteine-mediated BH4 oxidation effect, MTHFR impairment reduces BH4 recycling through a second mechanism: the dihydrobiopterin reductase (DHFR) enzyme that regenerates BH4 from BH2 requires dihydrofolate reductase activity an enzyme that uses NADPH to reduce both dihydrofolate to THF and BH2 to BH4
