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[60] Nintedanib [edit] Nintedanib is a triple angiokinase inhibitor that targets receptor tyrosine kinases involved in the regulation of angiogenesis: fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR), and vascular endothelial growth factor receptor (VEGFR), [61] which have also been implicated in the pathogenesis of fibrosis and IPF

Augmented activation of TLR4 increases oxidative stress and the generated ROS participate in signaling events downstream of TLRs

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