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A 2025 systematic review by Vasireddi and colleagues in HSS Journal screened 544 published papers and identified 36 meeting inclusion criteria 35 preclinical studies and only one human study: an uncontrolled, unblinded, retrospective case series of 12 patients receiving intra-articular BPC-157 for chronic knee pain, in which 7 of 12 (58%) reported self-described relief lasting more than 6 months, with no dose, effect size, or systematically collected adverse events published

Lower purity products may contain synthesis byproducts, degradation products, or contaminants that reduce effectiveness or introduce safety concerns

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Kannengiesser et al

3C), suggesting a possible compensatory mechanism or different metabolic response due to the absence of hepsin, potentially influencing vulnerability to and progression of APAP-induced liver injury

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