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However, as liraglutide was effective without functional adipose tissue present in our SKO mice, this implies it may be effective in partial lipodystrophy where adipose tissue is dysfunctional or reduced

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2013 Apr;13(2):298-306

Whereas the effect of GLP-1 was sensitive to the PKA inhibitor 8-Br-Rp-cAMPS, GLP-1(9-36) exerted its effect by a PKA-independent mechanism that was sensitive to pretreatment with pertussis toxin (implicating an inhibitory GTP-binding protein)

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A major new systematic review just out in the BMJ sums up 37 studies on what happens when people stop these meds