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Messenger-RNA changes generally require longer observation periods, while tissue remodeling and altered depot mass may require still longer experiments

I Santisteban, F X Arredondo-Vega, S Kelly, A Mary, A Fischer, D S Hummell, A Lawton, R U Sorensen, E R Stiehm, L Uribe To define the mechanism(s) responsible for the negative inotropic effects of tumor necrosis factor-alpha (TNF alpha) in the adult heart, we examined the functional effects of TNF alpha in the intact left ventricle and the isolated adult cardiac myocyte