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Absolute contraindications to GLP-1 receptor agonists include: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 Previous serious hypersensitivity reaction to the specific GLP-1 drug Pregnancy and breastfeeding (for medications approved for weight management: Wegovy, Saxenda, and Zepbound) Patients should maintain age-appropriate cancer screening regardless of GLP-1 use
in contrast, others highlight potential benefits, such as improved insulin sensitivity and enhanced blood circulation to the scalp
Real-world usage tells a different story, sometimes better, sometimes worse
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However, since GLP-1-RAs primarily operate by stimulating insulin secretion in a glucose-dependent manner, hypoglycemia is a rare occurrence
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