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Nonetheless, recent reports about weight regain have limited the effectiveness of GLP1R peptide agonists, sustaining the interest in expanding the chemical diversity of GLP-1R ligands through drug discovery strategies
Implications for treatment modality selection
Some studies link GLP-1 use to an increased risk for ocular diseases such as nonarteritic anterior ischemic optic neuropathy (NAION), diabetic retinopathy, papillitis, and optic nerve disorders
Additional potential biomarkers under investigation include serum homocysteine [36] and immune-based markers such as the neutrophil CD64 index and neutrophil to lymphocyte ratio (NLR) [37]
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Individuals with gastroparesis experienced persistent fullness even after consuming small amounts of food, along with acid reflux, nausea, vomiting, pain, bloating, and loss of appetite
