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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level

Reduced glutathione achieves this by attenuating ROS, which is important in the context of inflammation because ROS stimulates the activity of these proinflammatory cytokines

Acknowledgements We thank Kevin Vogt for helpful assistance in the preparation of this manuscript

Potentially the lung may be utilizing GSH from the plasma through an intact uptake mechanism shown to occur in the lung [27], which is then apically transported into the ELF, resulting in no net change in lung tissue GSH but a drastic increase in ELF GSH

Foods high in dietary protein such as beef , fish , and poultry also contain significant amounts of sulfur