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HNMT uses S-adenosyl-L-methionine (SAMe) as a methyl donor to convert histamine into an inactive form

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Research shows that NNMT inhibition promotes oxidative muscle fibers and preserves lean mass during weight loss

Dunphy JL, Taylor RG, Fuller PJ

Comparison of the effects of acetyl L-carnitine and amantadine for the treatment of fatigue inmultiple sclerosis: results of a pilot, randomised, double-blind, crossover trial