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Cardiovasc Res 101:364372 Imoukhuede PI, Dokun AO, Annex BH, Popel AS (2013) Endothelial cell-by-cell profiling reveals the temporal dynamics of VEGFR1 and VEGFR2 membrane localization after murine hindlimb ischemia
Evaluation of the Mechanism of the Brain Delivery As the main principle of the transporter-mediated approach is the use of the transporters for brain delivery of drugs, the confirmation of the utilization of the specific transporter by (pro)drugs, or nanocarriers for the BBB uptake should be confirmed
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21,22 Although clear protective benefits in diabetic retinopathy development and impact on disease progression remain under investigation, GLP-1RAs have been shown to reduce complications from chronic diabetes, such as retinal vein occlusion and cardiovascular disease
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