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Retatrutide is an investigational once-weekly subcutaneous peptide that activates GLP-1, GIP, and glucagon receptors simultaneously, aiming to suppress appetite and increase energy expenditure beyond the effect of existing approved agents
They are not interchangeable unless specifically indicated by research protocols
The semaglutide to tirzepatide conversion chart can help with dose matching, but supplement needs remain consistent regardless of which GLP-1 medication you use
The diagram in d was created using BioRender
doi:10.51253/pafmj.v73i2.3879 88 Oh WC, Mafrici B, Rigby M, et al
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