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"I don't give a **** what that idiot says about them or anything else." "Obesity is a complex, multifaceted, chronic disease, and GLP-1s correct a metabolic issue
It consists of a two-piece maxillary splint that overlies the palatal shelves and is retained by short medial pins
GLP-1R agonist liraglutide attenuates pain hypersensitivity by stimulating IL-10 release in a nitroglycerin-induced chronic migraine mouse model
Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach
The efficacy of semaglutide in controlling blood glucose levels and facilitating weight loss, along with the cardiovascular benefits demonstrated in the SUSTAIN-6 and PIONEER-6 trials, has expanded its clinical utility, potentially making it a first-line choice for many patients
Poster presentation 2008
