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Together, the two define the standard of care that every pipeline candidate must beat, which is why so much development effort has moved toward additional receptors and easier dosing rather than incremental gains on the same mechanism

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Louis, after the heart benefit ends they fade faster than they appeared in the first place

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We now know that patients frequently discontinue GLP-1 therapy within months, negating long-term benefits, and also struggle to meet the requirements of lifestyle changes that are prescribed alongside the medication

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