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Discussion In this study, we conducted a real-world assessment of GLP-1 efficacy over 12 months among US adults as compared to a matched set of controls who were clinically similar but likely pursued other therapeutic options to manage their weight and HbA1c

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Compared to placebo, the treatment with intramuscular acetyl-l-carnitine significantly reduced weekly mean pain on the VAS, whilst during the open-label part of the study, oral acetyl-l-carnitine improved symptoms in the entire cohort, with no safety issues [81] (Table 2)

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