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DPP-4 inhibitors were developed to prevent the enzymatic degradation of GLP-1 and GIP, thereby prolonging their activity and enhancing endogenous incretin effects

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Gastric GLP-1-positive cells are responsive to stimulation ex vivo and in vivo Fundus, antrum, or colon fragments from normal diet fed (ND) lean rat led to spontaneous release of GLP-1 ex vivo (Fig

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