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Collectively, our results with liraglutide and semaglutide show that long-acting GLP-1RAs have a role in the protection against atherosclerosis, mediated by a reduction in inflammatory pathways

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However, clinical studies on semaglutide for men have determined the weight loss drug rather quickly showed a 5-10% reduction in overall body weight for most patients

In most cases, the increases were dose and time dependent, and levels returned to baseline after a 1-month washout period