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Neither group responded to naloxone when given prior to ALC administration, however, the low LH group responded nicely with an increase in LH (normal response) after the 16 weeks (with a three-fold higher max LH pulse and overall 8-fold increase in amount of LH secreted)

Interestingly, we also show that kynurenine, a metabolite derived from tryptophan following inflammatory activation of IDO1 [46,47,48], is elevated in TTR-V30M patients but not in age-matched healthy controls

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M., Yang, Z