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In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus

This might arise early in the pathogenesis of T2DM, as one of many risk factors contributing to the initial onset of hyperglycaemia in susceptible individuals, or later, as a consequence of already existing metabolic changes causing increased DPP-4 activity and further exacerbating the deterioration of glycaemic control

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J Pharmacol Exp Ther 1998

How to Minimize Side Effects When Starting GLP-1 Beginning with the lowest therapeutic dose and advancing doses only every one to two weeks gives your gastrointestinal tract time to adjust without overwhelming your system