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For many people, nausea improves within a few weeks as the body adapts

For instance Liu et al

A 2025 University of Virginia study concluded that while GLP-1 drugs significantly reduce body weight and adiposity, they do so "with no clear evidence of cardiorespiratory fitness enhancement"a critical finding given that cardiorespiratory fitness is among the most potent predictors of all-cause and cardiovascular mortality [48]

Ultimately, 107 studies were included in this narrative review

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