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doi: 10.1021/acs.chemrev.6b00750 13 BlaskovicSBlancMvan der GootFG

It is sometimes searched for as 'the healing peptide' or 'gut healing peptide' due to its well-documented effects on gastrointestinal tissue repair

Abnormal mitochondrial function has been found to be present in patients with BD (60)

5 L of each sample was analysed on a Acquity UPLC HSS-T3 column (50 2.1 mm, 1.8 m, Waters, MA, USA) by using gradient elution of 0.1% formic acid ( v / v ) in water as mobile phase A and 0.1% formic acid ( v / v ) in acetonitrile as mobile phase B, with a flow rate of 0.4 mL/min with the following gradient: 00.5 min (0% B), 0.8 min (15% B), 1.2 min (80% B), 1.4 min (80% B), 1.5 min (0% B), 2 min (0% B)

Relative abundance of mRNA was normalized to ribosomal protein 36B4 ( Rplp0 )

Decreased P-gp expression leads to increased transport of certain substrates across the border into the brain while efflux of beta-amyloid out of the brain decreases, with resulting detrimental effects to the CNS microenvironment [65, 66]