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The compounds demonstrated different pharmacology in vivo, with TLC-2716 having lower plasma exposures and higher and sustained ileum and liver exposures (due to active uptake into hepatocytes) than TLC-6665 (ratio of AUCs of TLC-2716/TLC-6665 in plasma and liver of 0.17 and 6.24, respectively

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Regardless, it's an issue that's unlikely to get resolved anytime soon

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Zalachoras, I., Hollis, F., Ramos-Fernndez, E., Trovo, L., Sonnay, S., Geiser, E., Preitner, N., Steiner, P., Sandi, C., & Morat, L

Without Tesamorelin: Semaglutide creates deficit, body burns mostly subcutaneous fat, belly remains disproportionate