Research has revealed a unique protease activation phenomenon in MELAS: LONP1 exhibits subcellular compartmentalized aggregation in primary cells from patients with MELAS, with its protein abundance particularly elevated in cell populations enriched with mutant mtDNA
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Zimmermann DJ, Voss S, von Unruh GE, Hesse A
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Hypoxia and matrix metalloproteinase 13Responsive hydrogel microspheres alleviate osteoarthritis progression in vivo