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In a Phase IIb randomized, placebo-controlled trial involving about 160 patients, those who received monthly injections of ION224 for nearly a year showed marked improvements in liver fat, inflammation, and fibrosis, and remarkably, these benefits occurred even without weight loss

The medication also increases water retention in the intestinal lumen, which helps create satiety but may influence bowel habits and stool consistency

As noted by Lee, Cell Metabolism , MOTS-c improves insulin sensitivity and activates AMPK pathways, showing promise for obesity, diabetes, and metabolic dysfunction

A Doctors Perspective Ozempic, Mounjaro, Wegovy, Zepbound: Whats the Difference