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Conversely, those with lower-response markers benefit from progressing to 1.7 mg and potentially combining semaglutide with tirzepatide (a dual GLP-1/GIP agonist) for synergistic effect

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Furthermore, some studies suggest that semaglutide may have cardioprotective properties, potentially reducing the risk of cardiovascular events in individuals with obesity and type 2 diabetes

The prescribing information advises that individuals with a personal or family history of medullary thyroid carcinoma or a history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) should avoid GLP-1 agonists

Antitumor agents targeting GST in context are listed in Table 2