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These mechanisms transcend simple GLP-1 receptor activation, affecting the fundamental processes of inflammation, metabolism, and cellular survival, as depicted in Figure 2

Earlier studies demonstrated that the incretin effect of GIP was severely impaired in patients with uncontrolled T2DM (57)

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SGLT2 inhibitors, such as canagliflozin empagliflozin and dapagliflozin, suppress TEC apoptosis to ameliorate diabetic kidney damage (119, 124, 125)

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For the measurement of GLP-1, 30 human study participants with normal thyroid function were recruited (Supplementary Table 1)