When a physician recommends dose escalation or the introduction of new biological agents due to the inefficacy of the current regimen or a deterioration in health status
Ethical approval The Institutional Review Board approval is not required
Methylcobalamin is a commonly used form of vitamin B12 because it is one of the biologically active forms used by the body
Under extreme heat stress, cells produce a large amount of ROS, leading to oxidative stress and protein misfolding in the ER, resulting in ER stress and triggering ChaC1-associated UPR
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When fully dissociated, cells were centrifuged (230 g , 3 min) and the cell pellet resuspended and diluted to approximately 2.5E06 cells/mL in Recovery TM Cell Culture Freezing Medium (Gibco, #12648-010)