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PLoS One (2014) 9(3):e91769

Los ensayos aleatorios que examinaron la eficacia de los agonistas de GLP-1 para perder peso no fueron diseados para capturar estos eventos debido al pequeo tamao de las muestras y al corto seguimiento

Unlike many other antioxidants that we must consume through food, our bodies actually produce glutathione naturally

doi: 10.4049/jimmunol.173.5.3425 95 KnipperJAWillenborgSBrinckmannJBlochWMaaTWagenerRet al

The fundamental distinction lies in their mechanism: sulfonylureas provide continuous insulin stimulation (carrying intrinsic hypoglycaemia risk), whilst incretin mimetics offer glucose-responsive action with additional metabolic benefits beyond glycaemic control

Our choice of metformin as a proof-of-concept test as a CI inhibitor 79 in these orthotopic models was based on several factors: (1) it could easily be taken forward safely into in vivo studies with known target concentrations