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& Dai, Z
1 Next Steps and Future Implications These early insights from the COURAGE trial are consistent with recently published pre-clinical data in rodents and non-human primates and clearly establish the principle that blocking GDF8 with or without activin A can preserve muscle and further increase fat loss in patients being treated with GLP-1 therapy, thereby improving the quality of weight loss, continued Yancopoulos, in the press release
Its effects are more complex
Poe and Corn, 2020)
A supplementary analysis focusing specifically on retinopathy found consistent results, with semaglutide showing higher reporting odds than other drugs
The menstrual effects are related to weight loss and insulin sensitivity, not formulation differences
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