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not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile
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Retatrutide TRIUMPH-2/3: 22.6% Loss in Diabetes & CVD Lilly's retatrutide met endpoints in two new Phase 3 trials up to 22.6% weight loss in obesity with diabetes and heart disease
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By blocking NNMT, it helps preserve NAD+, a vital coenzyme your cells need for energy production and DNA repair
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