Morning administration is often recommended for several reasons: Consistency with routine : Taking supplements with breakfast helps establish a regular habit, improving adherence Perceived energy support : Although B12 doesn't provide immediate energy, taking it in the morning aligns with the body's natural circadian rhythm when energy demands are higher Avoiding potential sleep concerns : For individuals who report feeling more alert after taking B12, morning dosing eliminates any theoretical risk of evening alertness Absorption considerations are important when choosing timing
[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration
There is a reference to potential metabolic consequences, which may relate to the bodys regulation of energy and tissue equilibrium [4][5]
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Specialist hepatology input may be required for cirrhosis or hepatocellular carcinoma
And just like you, I so often have a patient come in and share a new study or a new protocol or a new thing