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Retatrutide Clinical Trial Results: The Data Phase 3 TRIUMPH-4 Trial (December 2025) The TRIUMPH-4 Phase 3 study enrolled 445 participants with obesity or overweight who also had knee osteoarthritis

Companies including Calibrate and Ro claim to have reached tens and hundreds of thousands of patients with their weight loss medication programs

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"About 4% of users who describe side effects report menstrual irregularities," said Sehgal

They found no link between these drugs and thyroid tumors in humans

Studies have shown that sertraline is just as effective as these medications in treating depression and anxiety