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The half-life of DSIP depends on its environment: In vitro, it exhibits low molecular stability due to the action of specific aminopeptidase enzymes, with a half-life of only 15 minutes

At 2.5 mg (starting dose, weeks 1 to 4) This is the lowest therapeutic dose, used primarily for tolerability assessment

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FOXO family isoforms

The mean blood glucose was significantly higher after a hot OGTT compared to a cold OGTT in both groups ( P = 0.002 and 0.028, respectively, Table 2, Figs

Worse still, their accumulation in tissues contributes to chronic inflammation, degenerative diseases and general ageing of the body