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Berthaut, I

De Magalhaes Filho CD et al

What Causes Skin to Darken or Become Uneven An uneven skin tone and dark patches are primarily caused by an overproduction of melanin in specific spots

When free radicals accumulate faster than your body can neutralize them, they damage cellular structures

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This discovery also exemplifies a broader principle in cell biology: the critical importance of metabolite and nutrient trafficking across organelle membranes in regulating cellular function and health