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Stool softeners containing docusate are also well-tolerated

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

Zhonghua Nan.Ke.Xue

Mice were studied as described in Figure 1A, and pancreatic sections were costained for insulin and glucagon