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After incubation of hemolyzed total blood with DTT, we observed a conjugation rate of GSH with CDNB higher than that found in the absence of reducing treatment, suggesting the presence of a significant, not spurious amount of oxidized e-GST (Figure 2a)

Blood collection and analysis During the week before initiation of the experimental protocol and 12 weeks after the initiation, fasting blood samples were taken from the antecubital vein into BD Vacutainer tubes (Becton, Dickinson and Company, Franklin Lakes, NJ, USA)

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Mechanism understanding helps troubleshooting non-responders, switching to peptides targeting different pathways potentially more relevant for specific individual pathophysiology

Cell 59 (19), 25322548

They can activate the same reward centers that addictive drugs do