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The active species is the cation CHN at 159.21 g/mol, and it is supplied as the iodide salt, CHIN, molecular weight 286.11 g/mol, CAS 42464-96-0
Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake
This cortisol-neutral profile is important because elevated cortisol is associated with increased appetite (particularly for high-calorie foods), abdominal fat accumulation, and metabolic complications
Oral administration is not viablegastric acid and hepatic first-pass metabolism degrade peptide bonds within minutes, rendering the compounds inactive before reaching systemic circulation
However, research into its mechanism and metabolic effects continues to provide valuable insights into selective fat tissue targeting
The Critical Caveat All of the above is based largely on animal studies
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