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This isnt just theory
Most researchers default to a 1000 mcg/ml concentration because the unit math is simple: 25 units = 250 mcg, 50 units = 500 mcg
Destabilization of the glycosyl bond between the nitrogenous base and ribose sugar creates apurinic sites as the unstable adducts are lost from DNA
This is consistent with the previous findings that hypoxia-response genes were upregulated in the islets of diabetic, but not prediabetic, db/db mice in an inverse relationship with unfolded protein response gene expression 28,33
Foot care in diabetes: the human and financial cost
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