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While the full long-term risk to humans is not yet known, the Black Box Warning exists due to concerning findings in animal studies and a lack of long-term human data

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Significantly elevated mucosal TPH1 expression in obese humans (38, 39) and elevated levels of circulating 5-HT in individuals with type 2 diabetes (T2D) (4042) or obesity (38) has been reported

The panels vote is not binding but is likely to embolden Health Secretary Robert F